Dr. Bi-Jie Li

Associate Professor

 

Research Directions:

Organometallic Chemistry
Physical Organic Chemistry
Asymmetric Catalysis

Biographical Sketch

Bi-Jie was born (1984) and raised up in southern China. In 2003, he began his undergraduate studies at Peking University and conducted undergraduate research in Prof. Zhang-Jie Shi’s lab. He obtained his bachelor degree with high honors in chemistry in 2007. In the same year, he began his graduate studies and worked with Prof. Zhang-Jie Shi at Peking University. In the Shi group, he developed a variety of methods for selective functionalization of inert C-O and C-H bonds. In the summer of 2012, he moved to University of California, Berkeley where he conducted his postdoctoral work in Prof. John Hartwig’s group. While in Berkeley, he worked on catalytic amidation and silylation of aliphatic C-H bonds. In July 2015, Dr. Li started his independent career in the chemistry department at Tsinghua University as an associate professor. His group aims to combine organometallic chemistry and physical organic chemistry to tackle challenging problems in organic synthesis. Currently, his research interests focus on ligand design, alkene functionalization and mechanistic studies.

 

Selected Publications

   Independent Research:
  1. Wang, Z.-X.; Bai, X.-Y.; Yao, H.-C.; Li, B.-J.* Synthesis of Amides with Remote Stereocenters by Catalytic Asymmetric γ-Alkynylation of α,β-Unsaturated Amides. J. Am. Chem. Soc. 2016, 138, 14872.
  2. X.-Y. Bai, Z.-X. Wang, B.-J. Li*, Iridium-Catalyzed Enantioselective Hydroalkynylation of Enamides for the Synthesis of Homopropargyl Amides, Angew. Chem. Int. Ed. 2016, 55, 9007-9011.
   Publications during Ph.D. Study and Postdoctoral Research:
  1. Z.-J. Shi*, B.-J. Li, X.-B. Wan, J. Cheng, Z. Fang, B. Cao, C.-M. Qin, Y. Wang, Suzuki-Miyaura Coupling Reaction by Pd(II)-Catalyzed Aromatic C-H Bond Activation Directed by an N-Alkyl Acetamino Group. Angew. Chem. Int. Ed. 2007, 46, 5554-5558.
  2. B.-J. Li, S.-L. Tian, Z. Fang, Z.-J. Shi*,Multiple C-H Activations to Construct Biologically Active Molecules in a Process Completely Free of Organohalogen and Organometallic Components. Angew. Chem. Int. Ed. 2008, 47, 1115-1118.
  3. B.-J. Li, Y.-Z. Li, X.-Y. Lu, J. Liu, B.-T. Guan, Z.-J. Shi*, Cross-Coupling of Aryl/Alkenyl Pivalates with Organozinc Reagents through Nickel-Catalyzed C-O Bond Activation under Mild Reaction Conditions. Angew. Chem. Int. Ed. 2008, 47, 10124-10127.
  4. Y.-Z. Li, B.-J. Li, X.-Y. Lu, S. Lin, Z.-J. Shi*, Cross Dehydrogenative Arylation (CDA) of a Benzylic C-H Bond with Arenes by Iron Catalysis. Angew. Chem. Int. Ed. 2009, 48, 3817-3820. (Equal contribution)
  5. B.-J. Li, L. Xu, Z.-H. Wu, B.-T. Guan, C.-L. Sun, B.-Q. Wang, Z.-J. Shi*, Cross-Coupling of Alkenyl/Aryl Carboxylates with Grignard Reagent via Fe-Catalyzed C-O Bond Activation. J. Am. Chem. Soc. 2009, 131, 14656-14657.
  6. B.-J. Li, Z.-J. Shi*, Ir-Catalyzed Highly Selective Addition of Pyridyl C–H Bonds to Aldehydes Promoted by Triethylsilane. Chem. Sci. 2011, 2, 488-493.
  7. B.-J. Li, H.-Y. Wang, Q.-L. Zhu; Z.-J. Shi*, Rhodium/Copper-Catalyzed Annulation of Benzimides with Internal Alkynes: Indenone Synthesis through Sequential C-H and C-N Cleavage. Angew. Chem. Int. Ed. 2012, 51, 3948-3952.
  8. B. L. Tran, B.-J. Li, M. Driess, J. F. Hartwig*, Copper-Catalyzed Intermolecular Amidation and Imidation of Unactivated Alkanes J. Am. Chem. Soc. 2014, 136, 2555-2563. (Equal contribution)
  9. B.-J. Li, M. Driess, J. F. Hartwig*, Iridium-Catalyzed Regioselective Silylation of Secondary Alkyl C–H Bonds for the Synthesis of 1,3-Diols. J. Am. Chem. Soc. 2014, 136, 6586-6589.

Office:
Room S906,
Mong Man Wai Building of Science and Technology

E-mail:
bijieli@mail.tsinghua.edu.cn

Telephone:
+86-10-6279-6627

Group Website