Dr. Jin-Pei Cheng

Center of Basic Molecular Science


Main Research Interests:

Physical Organic Chemistry
Organic Bond Energetics

Academic Experiences

2012-present Professor/Director, CBMS, Department of Chemistry,
Tsinghua University
2001-present Member of CAS, Member of TWAS
1990-present Professor/Joint Professor, Department of Chemistry, Nankai University
1988-1990 Associate Professor, Department of Chemistry, Nankai University
1987-1988 Postdoc, Department of Chemistry, Duke University (with Ned Arnett)
1982-1987 PhD study, Department of Chemistry, Northwestern University (with Fred Bordwell)
1981-1988 Lecturer, Department of Chemistry, Nankai University
1978-1981 MSc study, Department of Chemistry, Nankai University (with Chen-Heng Kao)
1972-1975 Undergraduate study, Department of Chemistry, Tianjin Normal University


Research Directions

Prof. Jin-Pei Cheng has developed various bond energy methodologies. On the basis of systematic determinations of many series of chemical bonds in conventional molecular solvents or in ionic liquids, Cheng was able to disclose a number of unknown phenomena and rules of theoretical or practical importance in chemistry and life sciences. Recently, he with team built the internet Bond-energy Databank (iBonD) for free access (see: http://ibond.nankai.edu.cn or http://ibond.chem.tsinghua.edu.cn). He is also one of the contributors (the only one from Asia) of CRC Handbook of Chemistry and Physics (in charge of BDEs) since 2012.


Representative Publications

  1. Xue, X.; Ji, P.; Zhou, B.; Cheng, J.-P. The Essential Role of Bond Energetics in C-H Activation/Functionalization. Chem. Rev., 2017, 117, 8622–8648.
  2. Yang, C.; Wang, J.; Liu, Y.; Ni, X.; Li, X.; Cheng, J.-P. Study on the Catalytic Behavior of Bifunctional Hydrogen-Bonding Catalysts Guided by Free Energy Relationship Analysis of Steric Parameters. Chem. Eur. J. 2017, 23, 5488-5497.
  3. Li, Z.; Li, X.; Cheng, J.-P. An Acidity Scale of Triazolium-Based NHC Precursors in DMSO. J. Org. Chem. 2017, 82, 9675-9681.
  4. Mao, C.; Wang, Z.-D.; Wang, Z.; Ji, P.; Cheng, J.-P. Weakly Polar Aprotic Ionic Liquids Acting as Strong Dissociating Solvent: A Typical “Ionic Liquid Effect” Revealed by Accurate Measurement of Absolute pKa of Ylide Precursor Salts. J. Am. Chem. Soc. 2016, 138, 5523.
  5. Dong, N.; Zhang, Z.-P.; Xue, X.-S.; Li, X.; Cheng, J.-P. Phosphoric Acid Catalyzed Asymmetric 1,6-Conjugate Addition of Thioacetic Acid to para-Quinone Methides. Angew. Chem. Int. Ed. 2016, 55, 1460-1464.
  6. Yang, C.; Zhang, E.-G.; Li, X.; Cheng, J.-P. Asymmetric Conjugate Addition of Benzofuran-2-ones to Alkyl 2-Phthalimidoacrylates: Modeling Structure-Stereoselectivity Relationships with Steric and Electronic Parameters. Angew. Chem. Int. Ed. 2016, 55, 6506-6510.
  7. Li, Z.; Li, X.; Ni, X.; Cheng, J.-P. Equilibrium Acidities of Proline Derived Organocatalysts in DMSO. Org. Lett. 2015, 17, 1196-1199.
  8. Wang, Z.-D.; Li, X.; Ji, P.; Cheng, J.-P. Absolute pKas of Sulfonamides in Ionic Liquids: Comparisons to Molecular Solvents. J. Org. Chem. 2016, 81, 11195.
  9. Xue, X.-S.; Wang, Y.; Yang, C.; Ji, P.; Cheng, J.-P. Toward Prediction of the Chemistry in Ionic Liquids: An Accurate Computation of Absolute pK(a) Values of Benzoic Acids and Benzenethiols. J. Org. Chem. 2015, 80, 8997-9006.
  10. Xue, X.; Li, X.; Yu, A.; Yang, C.; Song, C.; Cheng, J.-P. Mechanism and Selectivity of Bioinspired Cinchona Alkaloid Derivatives Catalyzed Asymmetric Olefin Isomerization: A Computational Study J. Am. Chem. Soc. 2013, 135, 7462-7473.

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