Dr. Lei Jiao

Associate Professor

 

Research Directions:

Reaction Mechanistic Study
Homogeneous Catalysis
Natural Product Synthesis

Biographical Sketch

Lei Jiao was born in Beijing in 1983. He obtained B.S. degree in Chemistry from Peking University in 2005 and Ph.D. in Chemistry with Prof. Zhi-Xiang Yu at Peking University in 2010. After a postdoctoral study with Prof. Thorsten Bach at Technische Universität München from 2010 to 2013, he started his independent career as a principle investigator in the Center of Basic Molecular Science at Tsinghua University in January 2014.

His research group interests in mechanistic study on organic reactions, mechanism-based design and development of new catalytic systems for C-H functionalization, and their application in natural product synthesis. He was selected as “the Recruitment Program of Global Experts (1000 Talents Plan for Young Scholars)” in 2014, and received Thieme Chemistry Journals Award (2014) and Qiu Shi Outstanding Young Scholar Award (2015).

 

Representative Publications

   Independent research:
  1. Revisiting the Radical Initiation Mechanism of the Diamine-Promoted Transition-Metal-Free Cross-Coupling Reaction
    Zhang, L.; Yang, H.; Jiao, L.* J. Am. Chem. Soc. 2016, 138, 7151-7160.
  2. Total Synthesis of (+)-Minfiensine: Construction of the Tetracyclic Core Structure by an Asymmetric Cascade Cyclization
    Zhang, Z.-X.; Chen, S.-C.; Jiao, L.* Angew. Chem. Int. Ed. 2016, 55, 8090-8094.
   Publications prior to Tsinghua:
  1. Palladium-Catalyzed Direct C–H Alkylation of Electron-Deficient Pyrrole Derivatives
    Jiao, L.; Bach, T.* Angew. Chem. Int. Ed. 2013, 52, 6080-6083.
  2. Pd(II)-Catalyzed Regioselective 2-Alkylation of Indoles via a Norbornene-Mediated C–H Activation: Mechanism and Applications
    Jiao, L.; Herdtweck, E.; Bach, T.* J. Am. Chem. Soc. 2012, 134, 14563-14572.
  3. Palladium-Catalyzed Direct 2-Alkylation of Indoles by Norbornene-Mediated Regioselective Cascade C–H Activation
    Jiao, L.; Bach, T.* J. Am. Chem. Soc. 2011, 133, 12990-12993.
  4. Density Functional Theory Study of the Mechanisms and Stereochemistry of the Rh(I)-Catalyzed Intramolecular [3+2] Cycloadditions of 1-Ene- and 1-Yne-Vinylcyclopropanes
    Jiao, L.; Lin, M.; Yu, Z.-X.* J. Am. Chem. Soc. 2011, 133, 447-461.
  5. Rh(I)-Catalyzed [(3+2)+1] Cycloaddition of 1-Yne/Ene-Vinylcyclopropanes and CO: Homologous Pauson-Khand Reaction and Total Synthesis of (±)-a-Agarofuran
    Jiao, L.; Lin, M.; Zhuo, L.-G.; Yu, Z.-X.* Org. Lett. 2010, 12, 2528-2531.
  6. Rh(I)-Catalyzed Intramolecular [3+2] Cycloadditions of 1-Ene-, 1-Yne- and 1-Allene-Vinylcyclo-propanes
    Jiao, L.; Lin, M.; Yu, Z.-X.* Chem. Commun. 2010, 46, 1059-1061.
  7. Rh(I)-Catalyzed Intramolecular [3+2] Cycloaddition of trans-Vinylcyclopropane-Enes
    Jiao, L.; Ye, S.; Yu, Z.-X.* J. Am. Chem. Soc. 2008, 130, 7178-7179.
  8. Tandem Rh(I)-Catalyzed [(5+2)+1] Cycloaddition/Aldol Reaction for the Construction of Linear Triquinane Skeleton: Total Syntheses of (±)-Hirsutene and (±)-1-Desoxyhypnophilin
    Jiao, L.; Yuan, C.; Yu, Z.-X.* J. Am. Chem. Soc. 2008, 130, 4421-4430.
  9. Origin of the Relative Stereoselectivity of the β-Lactam Formation in the Staudinger Reaction
    Jiao, L.; Liang, Y.; Xu, J.* J. Am. Chem. Soc. 2006, 128, 6060-6069.

Office:
Room S907,
Mong Man Wai Building of Science and Technology

E-mail:
Leijiao@
mail.tsinghua.edu.cn

Telephone:
+86-10-6278-8874

Group Website