杨金东，2009年本科毕业于南开大学；同年，进入南开大学元素有机国家重点实验室朱晓晴教授课题组攻读博士学位，在有机负氢转移反应的热力学、动力学及反应机理方面开展研究；2014-2017年在南开大学从事博士后研究（合作导师：程津培院士），主要从事有机化合物键能数据库（iBonD）的建设工作；2017年加入到清华大学基础分子科学中心程津培院士团队，2021年晋升为副研究员。主要围绕键能开展如下相关研究：有机化合物的键能测定；键能参数在反应机理研究、有机合成设计中的应用。曾获中国化学会物理有机化学新人奖（2019年）、入选中国科协青年人才托举工程（2019年）、入选北京市科协青年人才托举工程（2019年）、国家自然科学基金委优秀青年基金获得者（2022年）。

研究兴趣：化学键能量学、键能的应用、反应机理研究。

代表性论文：

1. Yang, J.-D.; Cheng, J.-P.^*; et al. Internet Bond-energy Databank (pK_a and BDE)-iBonD: http://ibond.nankai.edu.cn.

2. Xu, K.; Zhang, Y.-S.; Zhong, B.; Zhang, L.*; Yang, J.-D.*; Luo, S.*, Organocatalytic Hydrogen Evolution Reaction by Diazaphospholenes. J. Am. Chem. Soc. 2024, 146 25956-25962.

3. Xue, J.; Zhang, Y.-S.; Huan, Z.; Luo, H.-T.; Dong, L.; Yang, J.-D.*; Cheng, J.-P., Phosphonium-Catalyzed Monoreduction of Bisphosphine Dioxides: Origin of Selectivity and Synthetic Applications. J. Am. Chem. Soc. 2024, 146, 9335-9346.

4. Xue, J.; Zhang, Y.-S.; Huan, Z.; Yang, J.-D.*; Cheng, J.-P., Deoxygenation of Phosphine Oxides by P^III/P^V=O Redox Catalysis via Successive Isodesmic Reactions. J. Am. Chem. Soc. 2023, 145, 15589–15599.

5. Zhang, W.; Luo, H.-T.; Yang, J.-D.*, Breakthrough in phosphonylation of alkyl radicals: Alternative access of alkyl phosphonates. Chem 2023, 9, 2735-2737. 

6. Wu, J.-Y.; Mo, B.-R.; Yang, J.-D.*; Cheng, J.-P.*, A Distinctive Pattern for Substituent Effects on Transition Metal Centers: Enhanced Electron-Donating Capacity of Cationic Palladium Species. CCS Chem. 2022, 5, 1163-1175.

7. Zhang, J.; Yang, J.-D.*; Cheng, J.-P.*, Chemoselective catalytic hydrodefluorination of trifluoromethylalkenes towards mono-/gem-di-fluoroalkenes under metal-free conditions. Nat. Commun. 2021, 12, 2835.

8. Zhang, J.; Yang, J.-D.*; Cheng, J.-P.*, Recent progress in reactivity study and synthetic application of N-heterocyclic phosphorus hydrides. Natl. Sci. Rev. 2021, 8, nwaa253.

9. Wu, J.-Y.; Li, Z.; Yang, J.-D.*; Cheng, J.-P.*, Bonding Energetics of Palladium Amido/Aryloxide Complexes in DMSO: Implications for Palladium-Mediated Aniline Activation. Angew. Chem. Int. Ed. 2020, 59, 23782-23790.

10. Zhang, J.; Yang, J.-D.*; Cheng, J.-P.*, Diazaphosphinyl radical-catalyzed deoxygenation of α-carboxy ketones: a new protocol for chemo-selective C–O bond scission via mechanism regulation. Chem. Sci. 2020, 11, 8476-8481.

11. Zhang, J.; Yang, J.-D.*; Cheng, J.-P.*, Diazaphosphinanes as hydride, hydrogen atom, proton or electron donors under transition-metal-free conditions: thermodynamics, kinetics, and synthetic applications. Chem. Sci. 2020, 11, 3672-3679.

12. Zhang, J.; Yang, J.-D.*; Cheng, J.-P.*, Exploiting the radical reactivity of diazaphosphinanes in hydrodehalogenations and cascade cyclizations. Chem. Sci. 2020, 11, 4786-4790.

13. Luo, W.; Mao, C.; Ji, P.; Wu, J.-Y.; Yang, J.-D.*; Cheng, J.-P.*, Counterintuitive solvation effect of ionic-liquid/DMSO solvents on acidic C–H dissociation and insight into respective solvation. Chem. Sci. 2020, 11, 3365-3370.

14. Zhang, J.; Yang, J.-D.*; Cheng, J.-P.*, A Nucleophilicity Scale for the Reactivity of Diazaphospholenium Hydrides: Structural Insights and Synthetic Applications. Angew. Chem. Int. Ed. 2019, 58, 5983-5987.

15. Yang, J.-D.*; Xue, J.; Cheng, J.-P.*, Understanding the role of thermodynamics in catalytic imine reductions. Chem. Soc. Rev. 2019, 48, 2913-2926.

16. Zhang, J.#; Yang, J.-D.#; Zheng, H.; Xue, X.-S.*; Mayr, H.*; Cheng, J.-P.*, Exploration of the Synthetic Potential of Electrophilic Trifluoromethylthiolating and Difluoromethylthiolating Reagents. Angew. Chem. Int. Ed. 2018, 57, 12690-12695. (Co-first Author)

17. Yang, J.-D.#; Ji, P.#; Xue, X.-S.; Cheng, J.-P.*, Recent Advances and Advisable Applications of Bond Energetics in Organic Chemistry. J. Am. Chem. Soc. 2018, 140, 8611-8623. (Co-first Author)