学术带头人

程津培教授

研究方向:

物理有机化学
有机能量学
化学键键能的测定与计算

程津培,有机化学家,中国科学院院士(2001),第三世界科学院院士(TWAS,2001),清华大学基础分子科学中心主任(2012)。1975年毕业于天津师范学院,1981年获南开大学硕士,1987年获美国西北大学博士,1988年到南开大学工作(1995-2000年任副校长),2000-2008年担任国家科技部副部长。人大常委会委员、致公党中央副主席、国家教育咨询委员会委员、国家科技奖励委员会委员、欧美同学会副会长等职。

程津培教授主要从事物理有机化学研究,主要研究课题包括有机溶剂中各类化学键键能的方法学和实验测定、自由基稳定性理论、一氧化氮(NO)转移的热力学驱动力和机理、NADH辅酶模型的反应的热力学,动力学及机理、负氢热力学、叶立德(Ylide)稳定性的统一标度、离子液体中化合物pKa测定和有机小分子催化不对称有机反应机理等。

程津培教授在Science, Angewandte Chemie Internal Edition, Journal of the American Chemistry Society, The Journal of Organic Chemistry, Organic Letters, Chemistry - an European Journal, Chemical Communications等国内外著名刊物上发表了学术论文200余篇。这些论文已被国际论文他引5000余次,其中单篇最高他引达200余次。2005年获得何梁何利科学与技术进步奖。



代表性论文:

1.  Internet Bond-energy Databank (pKa and BDE)-iBonD: http://ibond.nankai.edu.cn.

2.  Wu, J.-Y.; Li, Z.; Yang, J.-D.*; Cheng, J.-P.* Bonding energetics of palladium-amido/aryloxide complexes in DMSO: implications for Pd-mediated aniline activation. Angew. Chem. Int. Ed. 2020, doi: 10.1002/anie.202011313.

3.  Zhang, J.; Yang, J.-D.*; Cheng, J.-P.* Recent progress in reactivity study and synthetic application of N-heterocyclic phosphorus hydrides. Natl. Sci. Rev. 2020. doi: 10.1093/nsr/nwaa253.

4.  Zhang, J.; Yang, J.-D.*; Cheng, J.-P.* Diazaphosphinyl radical-catalyzed deoxygenation of α-carboxy ketones: a new protocol for chemo-selective C–O bond scission via mechanism regulation. Chem. Sci. 2020, 11, 8476-8481.

5.  Zhang, J.; Yang, J.-D.*; Cheng, J.-P.* Exploiting the radical reactivity of diazaphosphinanes in hydrodehalogenations and cascade cyclizations. Chem. Sci. 2020, 11, 4786-4790.

6.  Zhang, J.; Yang, J.-D.*; Cheng, J.-P.* Diazaphosphinanes as hydride, hydrogen atom, proton or electron donors under transition-metal-free conditions: thermodynamics, kinetics, and synthetic applications. Chem. Sci. 2020, 11, 3672-3679.

7.  Luo, W.; Mao, C.; Ji, P.; Wu, J.-Y.; Yang, J.-D.*; Cheng, J.-P.* Counterintuitive solvation effect of ionic-liquid/DMSO solvents on acidic C–H dissociation and insight into respective solvation. Chem. Sci. 2020, 11, 3365-3370.

8. Zhang, J.; Yang, J.-D.*; Cheng, J.-P.* A Nucleophilicity scale for the reactivity of diazaphospholenium hydrides: structural insights and synthetic applications. Angew. Chem. Int. Ed. 2019, 58, 5983-5987.

9.  Yang, J.-D.*; Xue, J.; Cheng, J.-P.* Understanding the role of thermodynamics in catalytic imine reductions. Chem. Soc. Rev. 2019, 48, 2913-2926.

10. Zhang, J.; Yang, J.-D.; Zheng, H.; Xue, X.-S.*; Mayr, H.*; Cheng, J.-P. Exploration of the synthetic potential of electrophilic trifluoromethylthiolating and difluoromethylthiolating reagents. Angew. Chem. Int. Ed. 2018, 57, 12690-12695.

11. Yang, J.-D.; Ji, P.; Xue, X.-S.; Cheng, J.-P.* Recent advances and advisable applications of bond energetics in organic chemistry. J. Am. Chem. Soc. 2018, 140, 8611-8623.

12. Wang, Z.; Gao, F. X.; Ji, P.*; Cheng, J.-P.* Unexpected Solvation-stabilisation of Ions in a Protic Ionic Liquid: Insights Disclosed by a Bond Energetic Study. Chem. Sci. 2018, 9, 3538.

13. Xue, X.; Ji, P.; Zhou, B.; Cheng, J.-P.* The Essential Role of Bond Energetics in C-H Activation/Functionalization. Chem. Rev. 2017, 117, 8622–8648.

14. Mao, C.; Wang, Z.-D.; Wang, Z.; Ji, P.;* Cheng, J.-P.* Weakly Polar Aprotic Ionic Liquids Acting as Strong Dissociating Solvent: A Typical“Ionic Liquid Effect”Revealed by Accurate Measurement of Absolute pKa of Ylide Precursor Salts. J. Am. Chem. Soc. 2016, 138, 5523.

15. Dong, N.; Zhang, Z.-P.; Xue, X.-S.; Li, X.;* Cheng, J.-P.* Phosphoric Acid Catalyzed Asymmetric 1,6-Conjugate Addition of Thioacetic Acid to para-Quinone Methides. Angew. Chem. Int. Ed. 2016, 55, 1460-1464.

16. Yang, C.; Zhang, E.-G.; Li, X.;* Cheng, J.-P.* Asymmetric Conjugate Addition of Benzofuran-2-ones to Alkyl 2-Phthalimidoacrylates: Modeling Structure-Stereoselectivity Relationships with Steric and Electronic Parameters. Angew. Chem. Int. Ed. 2016, 55, 6506-6510.



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